BVD has a world-wide distribution and is characterized by high prevalence and relatively low morbidity. In addition to cows, other artiodactyla (sheep, goats, wild ruminants, pigs) can be infected...
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From an epidemiological point of view BVD virus is extremely successful. It occupies a special place viral pathogens thanks to its world-wide distribution and high rate of infection. It’s success is due to a combination of two well-known strategies, the “hit-and-run” strategy and the “infect-and persist” strategy... |
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If an antibody naïve cow is confronted with the virus during pregnancy its foetus may be infected in utero. This event has different consequences, depending on the time of infection... |
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Fetal infections in the middle of gestation (i.e. end of first trimester to beginning of last trimester) may generate malformations...
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Persistently infected animals do not produce detectable antibodies against “their” virus, i.e. they are immunotolerant. In large part PI-animals are clinically inconspicuous and will only be detected using laboratory techniques...
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